John Rambo has reserved himself to a simple and secluded life. The Vietnam Veteran spends his time capturing snakes and chauffeuring locals in his old boat. A group of Christian human rights missionaries rent Rambo's boat to travel up the Burma river. But when a slew of Burmese army men and their Major Pa Tee Tint attack the village they are visiting, Rambo joins a group of mercenaries to save them.