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A psychopath known as Buffalo Bill is kidnapping and murdering young women across the Midwest. Believing it takes one to know one, the FBI sends Agent Clarice Starling (Jodie Foster) to interview a demented prisoner who may provide psychological insight and clues to the killer's actions. The prisoner is psychiatrist Dr. Hannibal Lector (Anthony Hopkins), a brilliant, murderous cannibal who will only help Starling if she feeds his morbid curiosity with details about her own complicated life.